Biostimulators

  • Rejuvenation and anti-ageing
  • Long lasting results
  • Natural looking results
  • Improved skin quality
  • In-office procedure
  • Minimal downtime
  • Safe and Well-Researched
Biostimulators

What are biostimulators?

Biostimulator injections are a type of skin rejuvenation treatment that stimulates the body’s natural collagen production, reducing wrinkles and improving skin elasticity and contour.

Biostimulators are composed of biocompatible materials that are safely absorbed by the body, resulting in a skin tightening and lifting effect over time.

How do they work?

Collagen acts as the skin’s support structure. As we age, our body’s collagen production declines and our skin loses its firmness. Biostimulators introduce molecules that serve as scaffolds for collagen deposition. 

The body metabolizes these materials over several weeks to months, recruiting fibroblasts which leave behind newly formed type I and III collagen fibres that improve skin quality, leading to thicker, firmer skin. 

Improved microcirculation supports nutrient delivery, promoting healthier skin. Enhanced collagen and elastin networks restore elasticity, reducing skin laxity and improving facial contours. 

It is one of our go-to treatments to treat sagging skin in the lower face and neck and minimising the appearance of jowls.

Are there different types of biostimulators and what are they?

The different types of biostimulators have different modes of action that make them suitable for specific applications. 

The most popular injectable molecules are Poly-L-Lactic acid (PLLA), calcium hydroxyapatite and polycaprolactone. Due to the HPCSA’s ethical guidelines, we are not allowed to mention brand names, but at present we prefer the original FDA-approved Poly-L-Lactic acid (PLLA-SCA) biostimulator. 

We also use PDO threads (a special suture material) and a specific patented High Concentration Hyaluronic Acid (brand name withheld) to remodel collagen. Microneedling and PRP are also incredibly good methods of stimulating collagen formation. 

Exosomes and polynucleotides are also upcoming bio stimulants.

As with all our aesthetic treatments, an in-depth consultation is essential to help you make an informed decision about the best choice of biostimulator for your particular concern.

Unlike traditional dermal fillers that immediately provide volume, biostimulators gradually enhance facial contours, making the results incremental, natural and subtle. 

The results also generally last longer than with fillers – PLLA-SCA lasts up to 25 months. Biostimulators and fillers can be successfully used in combination, with a synergistic effect.

Is a biostimulator procedure painful?

Biostimulator treatments are performed in a similar manner as dermal fillers, with minimal discomfort during and after treatment. At the start of the treatment the injection entry points are injected with lidocaine, a local anaesthetic. 

The PLLA-SCA injection is also formulated with lidocaine. The treatment duration is usually 30 minutes to an hour. Patients can resume most of their normal activities afterwards.

What are the possible risks and complications associated with biostimulators?

Biostimulator treatments are considered safe when performed by a qualified healthcare professional. Potential risks and side effects are discussed during the initial consultation. 

The most common side effects of biostimulators include swelling, redness, bruising and tenderness at the injection site. These side effects typically resolve within a few days. 

Less common side effects may include lumps or nodules at the injection site, which may be due an inflammatory reaction. All side effects can be successfully managed and are transient in nature.

How soon will I see results after my first treatment?

The results of PLLA-SCA are gradual, with improvements appearing over several months, because it takes time for the body to produce new collagen and elastin fibres. Optimal results are seen after 3-6 months. 

Ultimately, the results are long-lasting, up to two years or more. The outcome of PLLA is optimised by doing a course of treatments. One vial is injected every 6-8 weeks, and we find that 2-3 vials are sufficient for most patients, although 1 vial is recommended per decade of life.

Who cannot do biostimulators?

Patients with a history of severe allergic reactions or autoimmune disorders should not undergo biostimulator treatments. Additionally, pregnant or breastfeeding women should avoid biostimulators, as their safety during pregnancy and lactation has not been established.

As with most injectables, patients with active infections are also excluded.

Before biostimulators, as with any of our treatments, your skin condition and facial structure is assessed using photographic technology and a clinical assessment. 

Your medical history, goals, and expectations will be discussed to determine a treatment plan tailored to your individual needs. 

The mechanism of action, results, potential side effects, and aftercare instructions for your recommended treatments will be discussed in detail.